Salermide

• CAT Number: I009277
• CAS Number: 1105698-15-4
• Molecular Formula: C₂₆H₂₂N₂O₂
• Molecular Weight: 394.47
• Purity: ≥95%
• Target: Sirtuin
• Solubility: Soluble in DMSO
• Storage: Store at +4C
• InChI: InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,27H,1H3,(H,28,30)/b24-17-
• InChIKey: UADRPWLRVLBVBC-ULJHMMPZSA-N
• SMILES: CC(C1=CC=CC=C1)C(=O)NC2=CC=CC(=C2)NC=C3C(=O)C=CC4=CC=CC=C43

Salermide (Cat.No:I009277) is a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Salermide was well tolerated by mice at concentrations up to 100 muM and prompted tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide was primarily because of a massive induction of apoptosis. Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells.

Reference

1:HDAC inhibitors, MS-275 and salermide, potentiates the anticancer effect of EF24 in human pancreatic cancer cells. Yar Saglam AS, Yilmaz A, Onen HI, Alp E, Kayhan H, Ekmekci A.EXCLI J. 2016 Apr 4;15:246-55. doi: 10.17179/excli2016-186. eCollection 2016. PMID: 27330528 Free PMC Article2:Combination of Salermide and Cholera Toxin B Induce Apoptosis in MCF-7 but Not in MRC-5 Cell Lines. Salahshoor MR, Dastjerdi MN, Jalili C, Mardani M, Khazaei M, Darehdor AS, Valiani A, Roshankhah S.Int J Prev Med. 2013 Dec;4(12):1402-13. PMID: 24498496 Free PMC Article3:Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A.J Med Chem. 2012 Dec 27;55(24):10937-47. doi: 10.1021/jm3011614. Epub 2012 Dec 12. PMID: 23189967 4:Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. Liu G, Su L, Hao X, Zhong N, Zhong D, Singhal S, Liu X.J Cell Mol Med. 2012 Jul;16(7):1618-28. doi: 10.1111/j.1582-4934.2011.01401.x. PMID: 21801305 Free PMC Article5:Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF.Oncogene. 2009 Feb 12;28(6):781-91. doi: 10.1038/onc.2008.436. Epub 2008 Dec 8. Erratum in: Oncogene. 2009 Feb 26;28(8):1168. Inhof, A [corrected to Imhof, A]. PMID: 19060927