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Rilmenidine

Rilmenidine

  • CAT Number: I014839
  • CAS Number: 54187-04-1
  • Molecular Formula: C₁₀H₁₆N₂O
  • Molecular Weight: 180.25
  • Purity: ≥95%
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Rilmenidine (Cat.No:I014839), an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells.

Catalog Number I014839
CAS Number 54187-04-1
Molecular Formula

C₁₀H₁₆N₂O

Purity 95%
Reference

[1]. Reid JL. Rilmenidine: a clinical overview. Am J Hypertens. 2000;13(6 Pt 2):106S-111S.<br>[2]. Srdic-Rajic T, et al. Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells. Eur J Pharm Sci. 2016;81:172-180.<br>[3]. Rose C, et al. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington’s disease. Hum Mol Genet. 2010;19(11):2144-2153.

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