| Catalog Number | R011341 |
| CAS Number | 14897-39-3 |
| Synonyms | 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-Acetate Sodium Salt; Rifamastene; Rifocin; Tuborin;
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| Molecular Formula | C37H46NO12 • Na
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| Purity | 95% |
| Storage | -20°C |
| Overview of Clinical Research | Rifamycin SV sodium is a DNA-directed RNA polymerase inhibitor developed by Cosmo Pharmaceuticals. It was registered for Traveller's diarrhoea in Italy.
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| IUPAC Name | sodium;(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-acetyloxy-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-27-olate |
| InChI | InChI=1S/C37H47NO12.Na.H2O/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);;1H2/q;+1;/p-1/b11-10+,14-13+,17-12-;;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;;/m0../s1 |
| InChIKey | YVOFSHPIJOYKSH-NLYBMVFSSA-M |
| SMILES | CC1C=CC=C(C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)[O-])C.[Na+] |
| Reference | <p>
1.<span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;"><span class="authors" data-text="Riva, S., and Silvestri, L.G." style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"><span style="box-sizing: border-box;"><span class="scientificMarkup" style="box-sizing: border-box;">Riva, S., and Silvestri, L.G.</span></span></span><span class="title" data-text="Rifamycins: A general view" style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"> <span style="box-sizing: border-box;"><span class="scientificMarkup" style="box-sizing: border-box;">Rifamycins: A general view</span></span>.</span><span class="journal" style="box-sizing: border-box; font-style: italic; font-variant-ligatures: normal; orphans: 2; widows: 2;"> Annu. Rev. Microbiol.</span><span class="number" style="box-sizing: border-box; font-weight: 700; font-variant-ligatures: normal; orphans: 2; widows: 2;"> 26,</span><span class="pagerange" style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"> 199-224</span><span class="year" style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"> (1982)</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">.<br />
2.</span><span class="authors" data-text="Kohanski, M.A., Dwyer, D.J., and Collins, J.J." style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"><span style="box-sizing: border-box;"><span class="scientificMarkup" style="box-sizing: border-box;">Kohanski, M.A., Dwyer, D.J., and Collins, J.J.</span></span></span><span class="title" data-text="How antibiotics kill bacteria: From targets to networks" style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"> <span style="box-sizing: border-box;"><span class="scientificMarkup" style="box-sizing: border-box;">How antibiotics kill bacteria: From targets to networks</span></span>.</span><span class="journal" style="box-sizing: border-box; font-style: italic; font-variant-ligatures: normal; orphans: 2; widows: 2;"> Nat. Rev. Microbiol.</span><span class="number" style="box-sizing: border-box; font-weight: 700; font-variant-ligatures: normal; orphans: 2; widows: 2;"> 8(6),</span><span class="pagerange" style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"> 423-435</span><span class="year" style="box-sizing: border-box; font-variant-ligatures: normal; orphans: 2; widows: 2;"> (2010)</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">.</span></span></span></p>
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