PX-478 hydrochloride

• CAT Number: I004578
• CAS Number: 685898-44-6
• Molecular Formula: C₁₃H₂₀Cl₄N₂O
• Molecular Weight: 394.11
• Purity: ≥95%
• Target: HIF
• Solubility: H2O: ≥ 35 mg/mL
• Storage: Store at -20°C
• IC50: 20-30 μM
• IUPAC Name: 4-[(2S)-2-amino-2-carboxyethyl]-N,N-bis(2-chloroethyl)benzeneamine oxide;dihydrochloride
• InChI: InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1
• InChIKey: GIGCDIVNDFQKRA-LTCKWSDVSA-N
• SMILES: C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

PX-478 2HCl（Cat No.:I004578） is a hypoxia-inducible factor-1α (HIF-1α) inhibitor that is orally active and selective. It effectively inhibits the activity of HIF-1α, a transcription factor involved in promoting adaptation to hypoxic conditions in tumor cells. By blocking HIF-1α, PX-478 2HCl can induce apoptosis, programmed cell death, and exhibits potent antitumor activity. This compound holds promise as a potential therapeutic agent for targeting HIF-1α in the treatment of various types of cancer.

Reference

[1]. Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437.
[2]. Welsh S, et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther. 2004 Mar;3(3):233-244.