Propargyl-PEG8-NH2

• CAT Number: I014643
• CAS Number: 1196732-52-1
• Molecular Formula: C19H37NO8
• Molecular Weight: 407.50
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
• InChI: InChI=1S/C19H37NO8/c1-2-4-21-6-8-23-10-12-25-14-16-27-18-19-28-17-15-26-13-11-24-9-7-22-5-3-20/h1H,3-20H2
• InChIKey: HJYYOUVXTIUMEJ-UHFFFAOYSA-N
• SMILES: C#CCOCCOCCOCCOCCOCCOCCOCCOCCN

Propargyl-PEG8-NH2(CAT: I014643) is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl (alkyne) group and a primary amine separated by an eight-unit PEG chain. The propargyl moiety enables efficient copper-catalyzed or strain-promoted azide–alkyne cycloaddition (“click chemistry”), while the amine group reacts readily with carboxylic acids, NHS esters, and other activated groups to form stable amide or carbamate linkages. The PEG8 spacer provides excellent solubility, hydrophilicity, and flexibility, reducing steric hindrance during conjugation. Propargyl-PEG8-NH2 is widely used in bioconjugation, drug delivery, PROTAC synthesis, nanomaterials, and surface modification, offering dual orthogonal reactivity and extended linker length for multifunctional molecular design.