BIX02188

• CAT Number: I003216
• CAS Number: 334949-59-6
• Molecular Formula: C25H24N4O2
• Molecular Weight: 412.493
• Purity: ≥95%
• Target: MEK5
• Solubility: DMSO: ≥ 45 mg/mL
• Storage: -20°C
• IC50: 4.3 nM
• IUPAC Name: (3Z)-3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxamide
• InChI: InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-
• InChIKey: FSZPIAXLCCQFCM-FCQUAONHSA-N
• SMILES: CN(C)CC1=CC(=CC=C1)NC(=C2C3=C(C=C(C=C3)C(=O)N)NC2=O)C4=CC=CC=C4

BIX02188(CAT: I003216) is a selective inhibitor of the protein kinase MEK, which plays a key role in the mitogen-activated protein kinase (MAPK) signaling pathway. This pathway regulates various cellular processes, including cell growth, differentiation, and survival. By inhibiting the activity of MEK, BIX02188 can block the activation of downstream signaling pathways and inhibit the growth and proliferation of cancer cells. BIX02188 has shown promising results in preclinical studies, and it is currently being evaluated for its potential use in cancer therapy.

Reference

[1]. Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun, 2008, 377(1), 120-125.
[2]. Li L, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun, 2008, 370(1), 159-163.