Tozasertib (VX-680, MK-0457, VX6)

• CAT Number: I004416
• CAS Number: 639089-54-6
• Molecular Formula: C₂₃H₂₈N₈OS
• Molecular Weight: 464.59
• Purity: ≥95%
• Target: Aurora Kinase
• Solubility: DMSO ≥90mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
• Storage: 3 years -20C powder
• IC50: 0.6 nM(Ki for Aurora A); 18 nM(Ki for Aurora B); 4.6 nM(Ki for Aurora C)
• InChI: InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
• InChIKey: GCIKSSRWRFVXBI-UHFFFAOYSA-N
• SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

Tozasertib (VX-680, MK-0457, VX6) (CAT: I004416) is a potent small molecule inhibitor of multiple protein kinases, including Aurora kinases A, B, and C. It disrupts the function of these kinases, which are involved in regulating cell division and mitosis. By inhibiting Aurora kinases, tozasertib interferes with the proper alignment and segregation of chromosomes during cell division, leading to cell cycle arrest and cell death. Tozasertib has demonstrated promising anti-tumor activity in preclinical studies and has been investigated in clinical trials for the treatment of various cancers, including hematological malignancies and solid tumors.

Reference

1:Tozasertib attenuates neuronal apoptosis via DLK/JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats. Yin C, Huang GF, Sun XC, Guo Z, Zhang JH.Neuropharmacology. 2016 Sep;108:316-23. doi: 10.1016/j.neuropharm.2016.04.013. Epub 2016 Apr 13. PMID: 27084696 2:ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib. Michaelis M, Selt F, Rothweiler F, Wiese M, Cinatl J Jr.BMC Res Notes. 2015 Sep 28;8:484. doi: 10.1186/s13104-015-1405-4. PMID: 26415506 Free PMC Article3:Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class. Salah E, Ugochukwu E, Barr AJ, von Delft F, Knapp S, Elkins JM.J Med Chem. 2011 Apr 14;54(7):2359-67. doi: 10.1021/jm101506n. Epub 2011 Mar 18. PMID: 21417343 Free PMC Article