Piperacillin Sodium

  • CAT Number: A000950
  • CAS Number: 59703-84-3
  • Molecular Formula: C23H26N5NaO7S
  • Molecular Weight: 539.5
  • Purity: ≥95%
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Piperacillin sodium is an antibiotic related to penicillin. Piperacillin binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis.

Catalog Number A000950
CAS Number 59703-84-3
Molecular Formula

C23H26N5NaO7S

Purity 95%
Storage -20°C
InChI 1S/C23H27N5O7S.Na/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);/q;+1/p-1/t13-,14-,15+,20-;/m1./s1
InChIKey WCMIIGXFCMNQDS-IDYPWDAWSA-M
SMILES CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
Reference

1: Leung E, Venkatesan N, Ly SC, Scheetz MH. Physical compatibility of vancomycin
and piperacillin sodium-tazobactam at concentrations typically used during
prolonged infusions. Am J Health Syst Pharm. 2013 Jul 1;70(13):1163-6. doi:
10.2146/ajhp120409. PubMed PMID: 23784164.
<br>

2: Gupta VD, Ling J. Stability of piperacillin sodium after reconstitution in
0.9% sodium chloride injection and storage in polypropylene syringes for
pediatric use. Int J Pharm Compd. 2001 May-Jun;5(3):230-1. PubMed PMID: 23981892.
<br>

3: Zhang Y, Xu QA, Trissel LA, Williams KY. Compatibility and stability of
linezolid injection admixed with aztreonam or piperacillin sodium. J Am Pharm
Assoc (Wash). 2000 Jul-Aug;40(4):520-4. PubMed PMID: 10932462.

<br>
4: Hahn Y, Son E. Electrochemical behavior and differential pulse polarographic
determination of piperacillin sodium. Arch Pharm Res. 2000 Jun;23(3):197-201.
PubMed PMID: 10896047.
<br>

5: Park TW, Le-Bui LP, Chung KC, Rho JP, Gill MA. Stability of piperacillin
sodium-tazobactam sodium in peritoneal dialysis solutions. Am J Health Syst
Pharm. 1995 Sep 15;52(18):2022-4. PubMed PMID: 8528873.
<br>

6: Chung KC, Moon YS, Chin A, Ulrich RW, Gill MA. Compatibility of ondansetron
hydrochloride and piperacillin sodium-tazobactam sodium during simulated Y-site
administration. Am J Health Syst Pharm. 1995 Jul 15;52(14):1554-6. PubMed PMID:
7552901.
<br>

7: Moon YS, Chung KC, Chin A, Gill MA. Stability of piperacillin
sodium-tazobactam sodium in polypropylene syringes and polyvinyl chloride
minibags. Am J Health Syst Pharm. 1995 May 1;52(9):999-1001. PubMed PMID:
7641040.
<br>

8: Moscato G, Galdi E, Scibilia J, Dellabianca A, Omodeo P, Vittadini G, Biscaldi
GP. Occupational asthma, rhinitis and urticaria due to piperacillin sodium in a
pharmaceutical worker. Eur Respir J. 1995 Mar;8(3):467-9. PubMed PMID: 7789496.
<br>

9: Mathew M, Das Gupta V, Bethea C. Stability of piperacillin sodium in the
presence of tazobactam sodium in 5% dextrose and normal saline injections. J Clin
Pharm Ther. 1994 Dec;19(6):397-9. PubMed PMID: 7876373.

<br>
10: Choi JS, Burm JP, Jhee SS, Chin A, Ulrich RW, Gill MA. Stability of
piperacillin sodium-tazobactam sodium and ranitidine hydrochloride in 0.9% sodium
chloride injection during simulated Y-site administration. Am J Hosp Pharm. 1994
Sep 15;51(18):2273-6. PubMed PMID: 7801988.

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