Piericidin A

• CAT Number: R001881
• CAS Number: 2738-64-9
• Molecular Formula: C25H37NO4
• Molecular Weight: 415.6
• Purity: ≥95%
• Target: Dehydrogenase
• Solubility: Soluble in DMSO
• Storage: -20°C
• InChIKey: BBLGCDSLCDDALX-LKGBESRRSA-N
• SMILES: COC1=C(O)C(C)=C(C/C=C(C)/C/C=C/C(C)=C/[C@H]([C@@H](O)/C(C)=C/C)C)N=C1OC

Piericidin A(cas 2738-64-9) is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces species.
It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface.

Reference

Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. Prieur I. et al. Biochim. Biophys. Acta 2001, 1504, 173.




H+/2e- stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. Galkin A.S. et al. FEBS Lett. 1999, 451, 157.


The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors. Darrouzet E. et al. FEBS Lett. 1998, 10, 34.

Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase. Friedrich T. et al. Eur J Biochem. 1994, 219, 691.