Pamidronate disodium pentahydrate

• CAT Number: I000403
• CAS Number: 109552-15-0
• Molecular Formula: C3H9NNa2O7P2
• Molecular Weight: 279.03
• Purity: ≥95%
• Solubility: H2O: ＞ 10 mg/mL
• Storage: 2-8°C
• IUPAC Name: disodium;[3-amino-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate;pentahydrate
• InChI: InChI=1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2
• InChIKey: CZYWHNTUXNGDGR-UHFFFAOYSA-L
• SMILES: C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].O.O.O.O.O.[Na+].[Na+]

Pamidronate disodium pentahydrate（Cat No.:I000403） is a nitrogen-containing bisphosphonate medication primarily used for the prevention and treatment of osteoporosis. It works by inhibiting bone resorption and reducing bone turnover. By binding to the bone matrix, pamidronate helps to strengthen bones and prevent fractures. It is commonly prescribed for conditions such as postmenopausal osteoporosis, Paget’s disease of bone, and bone metastases. Pamidronate is administered intravenously and its pentahydrate form ensures stability and solubility. 

Reference

[1]. Kubalek I, et al. Treatment of reflex sympathetic dystrophy with pamidronate: 29 cases. Rheumatology (Oxford). 2001 Dec;40(12):1394-7.
[2]. Zarychanski R, et al. Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol. 2006 Jan;81(1):73-5.