For research use only. Not for therapeutic Use.
PA452(CAT: I010686) is a selective retinoid X receptor (RXR) antagonist that blocks RXR-mediated transcriptional activity and modulates downstream retinoid signaling. It effectively inhibits the action of retinoic acid (RA) on Th1/Th2 immune cell development, highlighting its role in immune regulation. In cellular studies, PA452 suppresses troglitazone (TZ)-induced CK13 expression, and at concentrations of 0.01–1 μM, it inhibits RXR activity in normal human urothelial (NHU) cells. By selectively targeting RXR, PA452 provides a valuable pharmacological tool for exploring RXR-dependent signaling, immune differentiation, and retinoid-modulated pathways in both cancer and immunology research.
| CAS Number | 457657-34-0 |
| Molecular Formula | C26H37N3O3 |
| Purity | ≥95% |
| IUPAC Name | 2-[(3-hexoxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-methylamino]pyrimidine-5-carboxylic acid |
| InChI | InChI=1S/C26H37N3O3/c1-7-8-9-10-13-32-22-15-20-19(25(2,3)11-12-26(20,4)5)14-21(22)29(6)24-27-16-18(17-28-24)23(30)31/h14-17H,7-13H2,1-6H3,(H,30,31) |
| InChIKey | JJUUTJCZMGZJDZ-UHFFFAOYSA-N |
| SMILES | CCCCCCOC1=C(C=C2C(=C1)C(CCC2(C)C)(C)C)N(C)C3=NC=C(C=N3)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
