Garcinol

• CAT Number: I011871
• CAS Number: 78824-30-3
• Molecular Formula: C₃₈H₅₀O₆
• Molecular Weight: 602.8
• Purity: ≥95%
• Target: Histone Acetyltransferases
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20°C
• InChI: InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3
• InChIKey: DTTONLKLWRTCAB-UHFFFAOYSA-N
• SMILES: CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C

Garcinol (CAT: I011871) is a natural polyisoprenylated benzophenone derivative found in Garcinia indica, a plant native to Southeast Asia. It possesses diverse pharmacological activities, including antioxidant, anti-inflammatory, and anticancer properties. Garcinol exerts its effects through multiple mechanisms, such as modulation of transcription factors, inhibition of enzyme activity, and regulation of cellular signaling pathways. It has shown potential as a chemopreventive and chemotherapeutic agent, inhibiting the growth of various cancer cell lines and inducing apoptosis. Garcinol’s antioxidant and anti-inflammatory properties also make it a promising candidate for the treatment of oxidative stress-related diseases and inflammatory conditions.

Reference

1: Behera AK, Swamy MM, Natesh N, Kundu TK. Garcinol and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:435-452. Review. PubMed PMID: 27671827.
2: Liu C, Ho PC, Wong FC, Sethi G, Wang LZ, Goh BC. Garcinol: Current status of its anti-oxidative, anti-inflammatory and anti-cancer effects. Cancer Lett. 2015 Jun 28;362(1):8-14. doi: 10.1016/j.canlet.2015.03.019. Epub 2015 Mar 18. Review. PubMed PMID: 25796441.
3: Padhye S, Ahmad A, Oswal N, Sarkar FH. Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs. J Hematol Oncol. 2009 Sep 2;2:38. doi: 10.1186/1756-8722-2-38. Review. PubMed PMID: 19725977; PubMed Central PMCID: PMC2743703.