SC99

• CAT Number: I036098
• CAS Number: 882290-02-0
• Molecular Formula: C15H8Cl2FN3O
• Molecular Weight: 336.15
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(2-(3-Chloro-4-fluorophenyl)hydrazono)-3-(4-chlorophenyl)-3-oxo-propanenitrile
• InChI: InChI=1S/C15H8Cl2FN3O/c16-10-3-1-9(2-4-10)15(22)14(8-19)21-20-11-5-6-13(18)12(17)7-11/h1-7,20H/b21-14+
• InChIKey: ZKULFSMYRSFHKE-KGENOOAVSA-N
• SMILES: N#C/C(C(C1=CC=C(Cl)C=C1)=O)=NNC2=CC=C(F)C(Cl)=C2

SC99（Cat No.:I036098） is a selective inhibitor of JAK2-STAT3 activation, a signaling pathway involved in cell proliferation and survival. By targeting this pathway, SC99 downregulates the expression of several genes modulated by STAT3, including Bcl-2, Bcl-xL, VEGF, cyclin D2, and E2F-1. This inhibition has potential therapeutic implications in various diseases characterized by dysregulated JAK2-STAT3 signaling, such as cancer.

Reference

1: Ding Y, Qian J, Li H, Shen H, Li X, Kong Y, Xu Z, Chen G. Effects of SC99 on cerebral ischemia-perfusion injury in rats: Selective modulation of microglia polarization to M2 phenotype via inhibiting JAK2-STAT3 pathway. Neurosci Res. 2018 May 12. pii: S0168-0102(17)30594-1. doi: 10.1016/j.neures.2018.05.002. [Epub ahead of print] PubMed PMID: 29763638.
2: Xu Z, Xu YJ, Hao YN, Ren LJ, Zhang ZB, Xu X, Cao BY, Dai KS, Zhu L, Fang Q, Kong Y, Mao XL. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation. Acta Pharmacol Sin. 2017 May;38(5):651-659. doi: 10.1038/aps.2016.155. Epub 2017 Mar 6. PubMed PMID: 28260800; PubMed Central PMCID: PMC5457693.
3: Zhang Z, Mao H, Du X, Zhu J, Xu Y, Wang S, Xu X, Ji P, Yu Y, Cao B, Han K, Hou T, Xu Z, Kong Y, Jiang G, Tang X, Qiao C, Mao X. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget. 2016 Feb 23;7(8):9296-308. doi: 10.18632/oncotarget.6974. Erratum in: Oncotarget. 2016 Dec 6;7(49):81972. PubMed PMID: 26814430; PubMed Central PMCID: PMC4891041.