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ophiobolin C

ophiobolin C

  • CAT Number: M082949
  • CAS Number: 19022-51-6
  • Molecular Formula: C25H38O3
  • Molecular Weight: 386.6
  • Purity: ≥95%
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Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris.</br>Ophiobolin C inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells. Blockade of this binding was considered by scientists at Merck as a potential new mode of action for the treatment of HIV-1 infection.

Catalog Number M082949
CAS Number 19022-51-6
Molecular Formula

C25H38O3

Purity 95%
Target CCR5
Solubility Soluble in DMSO
Storage Store at -20°C
InChIKey PLWMYIADTRHIMY-BNFAVABNSA-N
Reference

The structure of zizannin-A and -B, C25-terpenoids isolated from Helminthosporium zizaniae. Nozoe S. et al. , Tetrahedron Lett. 1966, 7, 2211.<br/><br/>Isolation and structure of antagonists of chemokine receptor (CCR5). Jayasuriya et al. , H. J. Nat. Prod. 2004, 67, 1036.<br/><br/>The biology of ophiobolins. Au T.K. et al. , Life Sci. 2000, 67, 733. (Review).</span></p>

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