NSC3852

• CAT Number: I010574
• CAS Number: 3565-26-2
• Molecular Formula: C9H6N2O2
• Molecular Weight: 174.159
• Purity: ≥95%
• Target: HDAC
• Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol
• Storage: Store at RT
• IUPAC Name: 5-nitrosoquinolin-8-ol
• InChI: InChI=1S/C9H6N2O2/c12-8-4-3-7(11-13)6-2-1-5-10-9(6)8/h1-5,12H
• InChIKey: RZWRYPGAUIOOMK-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=CC(=C2N=C1)O)N=O

NSC3852 (CAT: I010574) is a chemically distinct histone deacetylase (HDAC) inhibitor that possesses a unique Zn2+ chelation motif different from that of SAHA (suberoylanilide hydroxamic acid). HDAC inhibitors are a class of compounds that target enzymes involved in the regulation of gene expression by removing acetyl groups from histone proteins, thus altering the chromatin structure and gene transcription. NSC3852’s unique Zn2+ chelation motif allows it to interact with HDAC enzymes, potentially influencing their activity and leading to changes in gene expression.

Reference

1: Strobl JS, Seibert CW, Li Y, Nagarkatti R, Mitchell SM, Rosypal AC, Rathore D,
Lindsay DS. Inhibition of Toxoplasma gondii and Plasmodium falciparum infections
in vitro by NSC3852, a redox active antiproliferative and tumor cell
differentiation agent. J Parasitol. 2009 Feb;95(1):215-23. doi:
10.1645/GE-1608.1. PubMed PMID: 18837587.

2: Martirosyan A, Leonard S, Shi X, Griffith B, Gannett P, Strobl J. Actions of a
histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive
oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor
cells. J Pharmacol Exp Ther. 2006 May;317(2):546-52. Epub 2006 Feb 23. PubMed
PMID: 16497787.