Novobiocin Sodium Salt

• CAT Number: A000332
• CAS Number: 1476-53-5
• Molecular Formula: C31H35N1NaO11
• Molecular Weight: 634.61
• Purity: ≥95%
• Target: Topoisomerase II
• Storage: 3 years -20C powder
• IUPAC Name: sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate
• InChI: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1
• InChIKey: WWPRGAYLRGSOSU-UHFFFAOYSA-M
• SMILES: CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]

Novobiocin sodium (CAS 1476-53-5) is an aminocoumarin antibiotic that prevents cell division. Novobiocin sodium is freely soluble in aqueous solution. Aminocoumarin antibiotics target DNA gyrase, an enzyme which relieves strain as DNA unwinds during replication and transcription.

Reference

1.Brown, Patrick O., and Craig L. Peebles. /Energy Coupling in DNA Gyrase and the Mechanism of Action of Novobiocin./ PNAS 75.2 (1978): 4838-842. Web. 21 Aug. 2012.
2.Benjama and Charkaoui, 1997, Control of Bacillus contaminating Date palm tissue in micro- propagation using antibiotics. Pathogen and microbial contamination management in micro- propagation. Kluwer academic publishers.