NCH 51

• CAT Number: I005086
• CAS Number: 848354-66-5
• Molecular Formula: C₂₀H₂₆N₂O₂S₂
• Molecular Weight: 390.56
• Purity: ≥95%
• Target: HDAC
• Solubility: DMSO:26mg/mL
• Storage: Store at 4°C
• IC50: 1-10 μM (EC50)
• InChI: InChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23)
• InChIKey: MDYDGUOQFUQOGE-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)SCCCCCCC(=O)NC1=NC(=CS1)C2=CC=CC=C2

NCH 51 (Cat.No:I005086) is a small molecule compound with potential anticancer activity. It selectively inhibits the protein kinase Pim-1, which plays a crucial role in promoting cell survival and proliferation. By targeting Pim-1, NCH 51 has the potential to inhibit tumor growth and metastasis, making it a promising candidate for cancer therapy. 

Reference

[1]. Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-1032.