MPT0E028

• CAT Number: I008145
• CAS Number: 1338320-94-7
• Molecular Formula: C17H16N2O4S
• Molecular Weight: 344.385
• Purity: ≥95%
• Target: HDAC inhibitor
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (E)-3-[1-(benzenesulfonyl)-2,3-dihydroindol-5-yl]-N-hydroxyprop-2-enamide
• InChI: InChI=1S/C17H16N2O4S/c20-17(18-21)9-7-13-6-8-16-14(12-13)10-11-19(16)24(22,23)15-4-2-1-3-5-15/h1-9,12,21H,10-11H2,(H,18,20)/b9-7+
• InChIKey: MGTIFSBCGGAZDB-VQHVLOKHSA-N
• SMILES: C1CN(C2=C1C=C(C=C2)C=CC(=O)NO)S(=O)(=O)C3=CC=CC=C3

MPT0E028 (Cat.No:I008145) is a small-molecule compound with potential anticancer activity. It belongs to the class of multi-kinase inhibitors and targets several signaling pathways involved in tumor growth and survival. MPT0E028 has shown promising preclinical activity against various cancer types, including lung, breast, and colorectal cancers. Further studies are being conducted to evaluate its therapeutic potential in clinical settings.

Reference

1:Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Huang HL, Peng CY, Lai MJ, Chen CH, Lee HY, Wang JC, Liou JP, Pan SL, Teng CM.Oncotarget. 2015 Mar 10;6(7):4976-91. PMID: 25669976 Free PMC Article2:Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo. Chen CH, Chen MC, Wang JC, Tsai AC, Chen CS, Liou JP, Pan SL, Teng CM.Clin Cancer Res. 2014 Mar 1;20(5):1274-87. doi: 10.1158/1078-0432.CCR-12-3909. Epub 2014 Feb 11. PMID: 24520095 Free PMC Article3:The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells. Chen MC, Chen CH, Wang JC, Tsai AC, Liou JP, Pan SL, Teng CM.Cell Death Dis. 2013 Sep 19;4:e810. doi: 10.1038/cddis.2013.330. PMID: 24052078 Free PMC Article4:Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo. Huang HL, Lee HY, Tsai AC, Peng CY, Lai MJ, Wang JC, Pan SL, Teng CM, Liou JP.PLoS One. 2012;7(8):e43645. doi: 10.1371/journal.pone.0043645. Epub 2012 Aug 22. Erratum in: PLoS One. 2012;7(9). doi: 10.1371/annotation/ab4fff87-6a32-4718-aa4c-91658f164b8d. Huang, Han-Lin [corrected to Huang, Han-Li]. PMID: 22928010 Free PMC Article