Lascufloxacin

• CAT Number: I007620
• CAS Number: 848416-07-9
• Molecular Formula: C21H24F3N3O4
• Molecular Weight: 439.43
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: 7-[(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxoquinoline-3-carboxylic acid
• InChI: InChI=1S/C21H24F3N3O4/c1-31-20-17-13(19(28)14(21(29)30)9-26(17)5-4-22)6-15(23)18(20)27-8-11(16(24)10-27)7-25-12-2-3-12/h6,9,11-12,16,25H,2-5,7-8,10H2,1H3,(H,29,30)/t11-,16+/m0/s1
• InChIKey: ZFIOCUITTUUVPV-MEDUHNTESA-N
• SMILES: COC1=C2C(=CC(=C1N3CC(C(C3)F)CNC4CC4)F)C(=O)C(=CN2CCF)C(=O)O

Lascufloxacin（Cat No.:I007620）, referred to by various names including KRP-AM-1977, KRP-AM-1977X, KRP-AM-1977Y, KRPAM-1977X, KRPAM-1977Y, and KRPAM-1977, is a novel antibacterial drug candidate. It belongs to the fluoroquinolone class of antibiotics and demonstrates promising potential in combating bacterial infections. Lascufloxacin exhibits a broad spectrum of activity against various bacterial strains, making it suitable for the treatment of different types of infections. As a novel drug candidate, further research and development are ongoing to determine its efficacy, safety, and potential role in clinical practice.

Reference

1:Antimicrob Agents Chemother. 2017 Mar 20. pii: AAC.00120-17. doi: 10.1128/AAC.00120-17. [Epub ahead of print] In vitro activities and spectrum of the novel fluoroquinolone, lascufloxacin (KRP-AM1977).Kishii R,Yamaguchi Y,Takei M, PMID: 28320717 DOI: 10.1128/AAC.00120-17 Abstract: Lascufloxacin showed a broad spectrum of activity against various clinical isolates. Especially, lascufloxacin showed the most potent activity against gram-positive bacteria among the quinolones tested. Furthermore, lascufloxacin showed incomplete cross-resistance against existing quinolone-resistant strains. Enzymatic analysis indicated that lascufloxacin showed potent inhibitory activity against both wild-type and mutated target enzymes. These results suggested that lascufloxacin may be useful in treating infections caused by various pathogens, including quinolone-resistant strains.Copyright © 2017 American Society for Microbiology.