KN-93 phosphate

• CAT Number: I002455
• CAS Number: 1913269-12-1
• Molecular Formula: C26H32ClN2O8PS
• Molecular Weight: 599.03
• Purity: ≥95%
• Target: CaMKII
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 370 nM (Ki); 12uM (NIH3T3 Cell) [1]

KN-93 phosphate (Cat.No:I002455) is a cell-permeable and water-soluble analog of KN-93, a potent inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). By blocking the activity of CaMKII, KN-93 phosphate interferes with various cellular processes and signaling pathways. It is commonly used in scientific research to study the functional roles of CaMKII in cellular physiology and pathology.

Reference

[1]. Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70.

[2]. Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15.

[3]. Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

[4]. Rokhlin OW, et al. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther. 2010 Feb;9(3):224-35.