ITSA-1

• CAT Number: I002540
• CAS Number: 200626-61-5
• Molecular Formula: C₁₃H₇Cl₂N₃O
• Molecular Weight: 292.12
• Purity: ≥95%
• Target: HDAC
• Solubility: DMSO ≥ 32 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H
• InChIKey: UVNLAUGZMOPBPR-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl

ITSA-1 (CAT: I002540) is a membrane-permeable compound that exhibits specific properties related to histone deacetylase (HDAC) inhibition. Unlike other HDAC inhibitors, ITSA-1 is known to selectively suppress the inhibition of HDAC caused by trichostatin A (TSA). HDACs are enzymes involved in the regulation of gene expression through histone deacetylation, impacting various cellular processes. ITSA-1’s unique ability to target TSA-mediated HDAC inhibition suggests its potential in modulating epigenetic mechanisms and cellular responses that involve HDAC activity.

Reference

[1]. Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10(5):397-410.