Gemifloxacin mesylate

• CAT Number: I002618
• CAS Number: 210353-53-0
• Molecular Formula: C18H20FN5O4 • CH3SO3H
• Molecular Weight: 485.5
• Purity: ≥95%
• Synonyms: LB 20304a;SB 265805S
• Solubility: DMSO:30mg/mL
• Storage: Store at -20°C
• IUPAC Name: 7-[(4Z)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;methanesulfonic acid
• InChI: InChI=1S/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27);1H3,(H,2,3,4)/b22-14+
• InChIKey: JIYMVSQRGZEYAX-CWUUNJJBSA-N
• SMILES: CO/N=C/1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F.CS(=O)(=O)O

Gemifloxacin mesylate (Cat.No:I002618) is an oral broad-spectrum quinolone antibacterial agent, used in the treatment of acute bacterial exacerbation of chronic bronchitis, and mild-to-moderate pneumonia.

Reference

1:Ingestion of the anti-bacterial agent, gemifloxacin mesylate, leads to increased gst activity and peroxidation products in hemolymph of Galleria mellonella l. (lepidoptera: pyralidae). Erdem M, Küçük C, Büyükgüzel E, Büyükgüzel K.Arch Insect Biochem Physiol. 2016 Dec;93(4):202-209. doi: 10.1002/arch.21352. Epub 2016 Sep 2. PMID: 27588824 2:Structural elucidation of gemifloxacin mesylate degradation product. Paim CS, Führ F, Martins MT, Gnoatto S, Bajerski L, Garcia CV, Steppe M, Schapoval EE.Biomed Chromatogr. 2016 Mar;30(3):459-65. doi: 10.1002/bmc.3569. Epub 2015 Sep 2. PMID: 26205148 3:Spectrophotometric method for the determination of Gemifloxacin mesylate in pure and tablet dosage form. Hassan SS, Hayat U, Tariq I, Ahmad I, Hayat MM, Uzair M, Ansari MT.Pak J Pharm Sci. 2014 Sep;27(5):1171-4. PMID: 25176374 4:HPTLC method for direct determination of gemifloxacin mesylate in human plasma. El-Koussi WM, Atia NN, Mahmoud AM, El-Shabouri SR.J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:98-101. doi: 10.1016/j.jchromb.2014.07.004. Epub 2014 Jul 11. PMID: 25086419 5:Highly selective colorimetric method to determine gemifloxacin mesylate in the presence of a synthetic impurity. Paim CS, Führ F, Miron DS, Steppe M, Schapoval EE.J AOAC Int. 2014 Jan-Feb;97(1):94-8. PMID: 24672864 6:Spectrofluorimetric determination of gemifloxacin mesylate and linezolid in pharmaceutical formulations: Application of quinone-based fluorophores and enhanced native fluorescence. Moussa BA, Mahrouse MA, Hassan MA, Fawzy MG.Acta Pharm. 2014 Mar;64(1):15-28. doi: 10.2478/acph-2014-0005. PMID: 24670349 7:Spectrophotometric determination of gemifloxacin mesylate, moxifloxacin hydrochloride, and enrofloxacin in pharmaceutical formulations using Acid dyes. Gouda AA, Amin AS, El-Sheikh R, Yousef AG.J Anal Methods Chem. 2014;2014:286379. doi: 10.1155/2014/286379. Epub 2014 Jan 22. PMID: 24587941 Free PMC Article8:Gemifloxacin mesylate (GFM): dissolution test based on in vivo data. Paim CS, Verlindo de Araújo B, Volpato NM, Steppe M, Schapoval EE.Drug Dev Ind Pharm. 2015 Apr;41(4):567-72. doi: 10.3109/03639045.2014.884128. Epub 2014 Feb 12. PMID: 24517572 9:Two validated spectrofluorometric methods for determination of gemifloxacin mesylate in tablets and human plasma. Atia NN, Mahmoud AM, El-Shabouri SR, El-Koussi WM.Int J Anal Chem. 2013;2013:137279. doi: 10.1155/2013/137279. Epub 2013 May 16. PMID: 23762060 Free PMC Article10:Spectrofluorimetric analysis of gemifloxacin mesylate in pharmaceutical formulations. Al-Tamimi SA, Alarfaj NA, Aly FA, Al-Mohaimeed AM.Luminescence. 2014 Mar;29(2):127-31. doi: 10.1002/bio.2515. Epub 2013 May 17. PMID: 23681953