Furazolidone

  • CAT Number: A000092
  • CAS Number: 67-45-8
  • Molecular Formula: C8H7N3O5
  • Molecular Weight: 225.16
  • Purity: ≥95%
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Furazolidone is a nitrofuran antibacterial agent. It is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.

Catalog Number A000092
CAS Number 67-45-8
Synonyms

NA

Molecular Formula

C8H7N3O5

Purity 95%
Storage Store at -20°C
InChI 1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
InChIKey PLHJDBGFXBMTGZ-WEVVVXLNSA-N
SMILES C1COC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-]
Reference

1: Zamani M, Rahbar A, Shokri-Shirvani J. Resistance of Helicobacter pylori to
furazolidone and levofloxacin: A viewpoint. World J Gastroenterol. 2017 Oct
7;23(37):6920-6922. doi: 10.3748/wjg.v23.i37.6920. PubMed PMID: 29085236; PubMed
Central PMCID: PMC5645626.
<br>

2: Mohammadi M, Attaran B, Malekzadeh R, Graham DY. Furazolidone, an
Underutilized Drug for H. pylori Eradication: Lessons from Iran. Dig Dis Sci.
2017 Aug;62(8):1890-1896. doi: 10.1007/s10620-017-4628-5. Epub 2017 Jun 2.
Review. PubMed PMID: 28577244; PubMed Central PMCID: PMC5527993.
<br>

3: Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S. Involvement of the activation of
Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in
furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02
cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi:
10.1080/15376516.2016.1273424. Epub 2017 Jan 8. PubMed PMID: 27996348.
<br>

4: Cheng H, Hu FL, Sheng JQ, An HJ, Xu L, Liu FX, Li Y, Hao Q, Zheng PY, Lu GF,
Cao ZQ, Wang YP. [Jinghuaweikang capsules combined with furazolidone-based triple
or quadruple therapy as the rescue treatment for Helicobacter pylori infection: a
multicenter randomized controlled clinical trial]. Zhonghua Yi Xue Za Zhi. 2016
Nov 1;96(40):3206-3212. doi: 10.3760/cma.j.issn.0376-2491.2016.40.002. Chinese.
PubMed PMID: 27852385.
<br>

5: Dai C, Li D, Gong L, Xiao X, Tang S. Curcumin Ameliorates Furazolidone-Induced
DNA Damage and Apoptosis in Human Hepatocyte L02 Cells by Inhibiting ROS
Production and Mitochondrial Pathway. Molecules. 2016 Aug 22;21(8). pii: E1061.
doi: 10.3390/molecules21081061. PubMed PMID: 27556439.

<br>
6: Avais M, Rashid G, Ijaz M, Khan MA, Nasir A, Jahanzaib MS, Khan JA, Hameed S,
Reichel MP. Evaluation of furazolidone, sulfadimidine and amprolium to treat
coccidiosis in Beetal goats under field conditions. Pak J Pharm Sci. 2016
Mar;29(2):485-7. PubMed PMID: 27087093.
<br>

7: Shahrokhian S, Naderi L, Ghalkhani M. Modified glassy carbon electrodes based
on carbon nanostructures for ultrasensitive electrochemical determination of
furazolidone. Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:842-50. doi:
10.1016/j.msec.2016.01.025. Epub 2016 Jan 12. PubMed PMID: 26838915.

<br>
8: Alam MI, Paget T, Elkordy AA. Formulation and advantages of furazolidone in
liposomal drug delivery systems. Eur J Pharm Sci. 2016 Mar 10;84:139-45. doi:
10.1016/j.ejps.2016.01.017. Epub 2016 Jan 18. PubMed PMID: 26796143.

<br>
9: Deng S, Tang S, Dai C, Zhou Y, Yang X, Li D, Xiao X. P21(Waf1/Cip1) plays a
critical role in furazolidone-induced apoptosis in HepG2 cells through
influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016
Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11. PubMed PMID:
26687534.
<br>

10: Mokhtare M, Hosseini V, Tirgar Fakheri H, Maleki I, Taghvaei T, Valizadeh SM,
Sardarian H, Agah S, Khalilian A. Comparison of quadruple and triple Furazolidone
containing regimens on eradication of helicobacter pylori. Med J Islam Repub
Iran. 2015 Apr 6;29:195. eCollection 2015. PubMed PMID: 26157713; PubMed Central
PMCID: PMC4476222.

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