Fluralaner

• CAT Number: I006822
• CAS Number: 864731-61-3
• Molecular Formula: C22H17Cl2F6N3O3
• Molecular Weight: 556.3
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: -20°C
• IUPAC Name: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide
• InChI: InChI=1S/C22H17Cl2F6N3O3/c1-11-4-12(2-3-16(11)19(35)31-9-18(34)32-10-21(25,26)27)17-8-20(36-33-17,22(28,29)30)13-5-14(23)7-15(24)6-13/h2-7H,8-10H2,1H3,(H,31,35)(H,32,34)
• InChIKey: MLBZKOGAMRTSKP-UHFFFAOYSA-N
• SMILES: CC1=CC(C2=NOC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)C2)=CC=C1C(NCC(NCC(F)(F)F)=O)=O

Flurapana (CAT: I006822) is an oral systemic insecticide and acaricide that acts primarily by interfering with GABA-gated chloride channels. Its toxicity is higher than or equivalent to commonly used insecticides. This product is used for medical research and development and other scientific research purposes.

Reference

1. Parasit Vectors. 2014 Mar 19;7:105. doi: 10.1186/1756-3305-7-105.
Safety of the concurrent treatment of dogs with Bravecto (fluralaner) and Scalibor protectorband (deltamethrin).
Walther FM(1), Fisara P, Allan MJ, Roepke RK, Nuernberger MC.
Author information:
(1)MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany. .
BACKGROUND: Bravecto (fluralaner; MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. Scalibor Protectorband (deltamethrin; MSD Animal Health) is a collar often used to reduce sandfly feeding for leishmaniasis prevention. This study investigated the safety of the concurrent use of Bravecto and Scalibor Protectorband at the recommended dosage regimens.
FINDINGS: Throughout the study period of 24 weeks, there were no clinical findings related to the concurrent treatment with Bravecto in dogs fitted with Scalibor Protectorband at the recommended dosage regimen.
CONCLUSIONS: Concurrent treatment with Bravecto in dogs fitted with Scalibor Protectorband is well tolerated.
2. Parasit Vectors. 2014 Mar 6;7:86. doi: 10.1186/1756-3305-7-86.
Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1(-/-) Collies after oral administration.
Walther FM(1), Paul AJ, Allan MJ, Roepke RK, Nuernberger MC.
Author information:
(1)MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany. .
BACKGROUND: Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies.
METHODS: Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. Eight Collies received fluralaner chewable tablets once at a dose of 168 mg/kg; eight sham dosed Collies served as controls. All Collies were clinically observed until 28 days following treatment.
RESULTS: No adverse events were observed subsequent to fluralaner treatment of MDR1(-/-) Collies at three times the highest expected clinical dose. CONCLUSIONS: Fluralaner chewable tablets are well tolerated in MDR1(-/-) Collies following oral administration.