Escitalopram oxalate (Cat. No: A000710) is a new type of SSRIS drug, which mainly mediates the inhibitory effect of citalopram on 5-HT reuptake, and has a high affinity for low affinity allosteric binding sites. It has become the first-line drug for the treatment of depression by inhibiting 5-HT transporter (SERT) in a highly selective dose-dependent manner and inhibiting 5-HT reuptake in the presynaptic membrane of nerve endings in the central nervous system.
Catalog Number | A000710 |
CAS Number | 219861-08-2 |
Synonyms | 219861-08-2; Lexapro; Cipralex; (S)-Citalopram Oxalate; Escitalopram (oxalate) |
Molecular Formula | C22H23FN2O5 |
Purity | 95% |
Target | SSRIs |
Solubility | Soluble in DMSO > 10 mM |
Storage | -20°C |
InChI | 1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1 |
InChIKey | KTGRHKOEFSJQNS-BDQAORGHSA-N |
SMILES | CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.C(=O)(C(=O)O)O |
Reference | 1: Chen VC, Hsieh YH, Chen LJ, Hsu TC, Tzang BS. Escitalopram oxalate induces 2: Attia K Ali, Mohamed AM, Fekry MA. Electroanalytical Determination of <br> 4: Ma L, Lu ZN, Hu P, Yao CJ. Neuroprotective effect of escitalopram oxalate in 5: Khanna S, Chirinos RE, Venna S. Escitalopram oxalate (Lexapro)-induced 6: Kakde RB, Satone DD, Gadapayale KK, Kakde MG. Stability-indicating RP-HPLC <br> <br> 9: Sharma S, Rajpurohit H, Sonwal C, Bhandari A, Choudhary V, Jain T. Zero order <br> |