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Epetraborole hydrochloride

Epetraborole hydrochloride

  • CAT Number: I000933
  • CAS Number: 1234563-16-6
  • Molecular Formula: C11H16BNO4 • HCl
  • Molecular Weight: 273.5
  • Purity: ≥95%
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Epetraborole hydrochloride (Cat.No:I000933) is a novel antibiotic under development. It targets the bacterial enzyme leucyl-tRNA synthetase, essential for protein synthesis. Epetraborole disrupts bacterial growth by inhibiting this enzyme, making it a potential treatment option for multidrug-resistant Gram-negative infections. Further research is being conducted to explore its therapeutic efficacy.

Catalog Number I000933
CAS Number 1234563-16-6
Molecular Formula

C11H16BNO4 • HCl

Purity 95%
Target Synthases/Synthetases
Solubility H2O ≥ 28 mg/mL
Storage Store at -20°C
InChIKey DADYQGIQOBJGIW-HNCPQSOCSA-N
Reference

<p style=/line-height:25px/>
<br>[1]. Goldstein EJ et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms.
Antimicrob Agents Chemother. 2013 May;57(5):2401-4.

<br>[2]. O/’Dwyer K et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment ofcomplicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.

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