Elubrixin tosylate

• CAT Number: I014824
• CAS Number: 960495-43-6
• Molecular Formula: C24H25Cl2FN4O7S2
• Molecular Weight: 635.51
• Purity: ≥95%
• Synonyms: 1-(2-chloro-3-fluorophenyl)-3-(4-chloro-2-hydroxy-3-piperazin-1-ylsulfonylphenyl)urea;4-methylbenzenesulfonic acid
• InChI: InChI=1S/C17H17Cl2FN4O4S.C7H8O3S/c18-10-4-5-13(23-17(26)22-12-3-1-2-11(20)14(12)19)15(25)16(10)29(27,28)24-8-6-21-7-9-24;1-6-2-4-7(5-3-6)11(8,9)10/h1-5,21,25H,6-9H2,(H2,22,23,26);2-5H,1H3,(H,8,9,10)
• InChIKey: CJAUWWGOABMMJX-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1CN(CCN1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl

Elubrixin tosylate（Cat No.:I014824）is a small-molecule antagonist of the chemokine receptor CXCR2, a receptor involved in neutrophil chemotaxis, inflammation, and tumor progression. By blocking CXCR2 signaling, Elubrixin tosylate reduces neutrophil infiltration into inflamed tissues and modulates the tumor microenvironment, offering potential benefits in both inflammatory diseases and oncology. The tosylate salt form improves stability and handling for laboratory use. Elubrixin tosylate serves as a valuable research tool for investigating chemokine-driven immune responses, chronic inflammatory conditions, and the development of targeted therapeutic strategies in cancer and immunology.