Azoramide

• CAT Number: I005538
• CAS Number: 932986-18-0
• Molecular Formula: C15H17ClN2OS
• Molecular Weight: 308.8
• Purity: ≥95%
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: -20°C
• IUPAC Name: N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
• InChI: InChI=1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
• InChIKey: VYBFWKKCWTXCQX-UHFFFAOYSA-N
• SMILES: CCCC(=O)NCCC1=CSC(=N1)C2=CC=C(C=C2)Cl

Azoramide (Cat No.: I005538) is a small molecule regulator of unfolded protein response to UPR, which can improve the folding ability of endoplasmic reticulum proteins, activate the ability of ER chaperones, and protect proteins from the endoplasmic reticulum stress response. Azoramide also improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Treatment with azoramide significantly improved insulin sensitivity and glucose tolerance, as well as β-cell function, in multiple preclinical models of obese mice.

Reference

1:Azoramide: a new drug for the treatment of type 2 diabetes? Guillen C.Ann Transl Med. 2016 Oct;4(Suppl 1):S45. No abstract available. PMID: 27868013 Free PMC Article2:Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS.Sci Transl Med. 2015 Jun 17;7(292):292ra98. doi: 10.1126/scitranslmed.aaa9134. PMID: 26084805 Free PMC Article