Ecopipam hydrobromide

For research use only. Not for therapeutic Use.

  • CAT Number: I045639
  • CAS Number: 2587360-22-1
  • Molecular Formula: C19H21BrClNO
  • Molecular Weight: 394.73
  • Purity: ≥95%
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Ecopipam hydrobromide (Cat No.: I045639) is a selective antagonist of the dopamine D1 receptor, investigated for its potential in treating neurological and psychiatric disorders. By blocking D1 receptor activity, it modulates dopaminergic signaling, influencing motor control, reward pathways, and behavior. Ecopipam has been studied in conditions such as Tourette syndrome, obesity, and addiction. The hydrobromide salt improves solubility and stability for research and clinical applications. Although still under investigation, ecopipam hydrobromide remains a valuable compound in exploring dopamine-related pathways and therapeutic strategies.


CAS Number 2587360-22-1
Synonyms

(6aS,13bR)-11-chloro-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol;hydrobromide

Molecular Formula C19H21BrClNO
Purity ≥95%
InChI InChI=1S/C19H20ClNO.BrH/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21;/h2-5,10-11,17,19,22H,6-9H2,1H3;1H/t17-,19+;/m0./s1
InChIKey GAUWIDFICGEZKR-JUOYHRLASA-N
SMILES CN1CCC2=CC(=C(C=C2C3C1CCC4=CC=CC=C34)O)Cl.Br
Reference

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[2]. Sharopov S, et al. Dopaminergic modulation of low-Mg²⁺-induced epileptiform activity in the intact hippocampus of the newborn mouse in vitro. J Neurosci Res. 2012 Oct;90(10):2020-33.
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[3]. Satanove DJ, et al. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects. Psychopharmacology (Berl). 2021 Feb;238(2):475-486.
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[4]. R E Chipkin, et al. Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity. J Pharmacol Exp Ther. 1988 Dec;247(3):1093-102.
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[5]. E Acquas, et al. Local application of SCH 39166 reversibly and dose-dependently decreases acetylcholine release in the rat striatum. Eur J Pharmacol. 1999 Nov 3;383(3):275-9.
[Content Brief]

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