Dyclonine HCl

  • CAT Number: A000385
  • CAS Number: 536-43-6
  • Molecular Formula: C18H27NO2.HCl
  • Molecular Weight: 325.87
  • Purity: ≥95%
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Dyclonine Hydrochloride is an oral local anesthetic. Dyclonine reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane/’s permeability to sodium ions, leading to an increased threshold for excitation. This reversibly stabilizes the membrane and inhibits depolarization, leading to the failure of a propagated action potential and subsequent conduction blockade. This results in a transient and reversible loss of sensation in a localized area of the body.

Catalog Number A000385
CAS Number 536-43-6
Molecular Formula

C18H27NO2.HCl

Purity 95%
Storage 3 years -20C powder
Reference

</br>1: Schmidt AC. Solid-state characterization of falicaine hydrochloride and</br> isomorphic dyclonine hydrochloride. Part IV. Crystal polymorphism of local</br> anaesthetic drugs. Eur J Pharm Sci. 2005 Jul-Aug;25(4-5):407-16. PubMed PMID:</br> 15896948.</br>2: Bacon GS, Lyons TR, Wood SH. Dyclonine hydrochloride for airway anesthesia:</br> awake endotracheal intubation in a patient with suspected local anesthetic</br> allergy. Anesthesiology. 1997 May;86(5):1206-7. PubMed PMID: 9158369.</br>3: Liang CY, Yang Y, Khadim MA, Banker GS, Kumar V. Isolation and</br> characterization of two major degradation products of dyclonine hydrochloride. J </br> Pharm Sci. 1995 Sep;84(9):1141-3. PubMed PMID: 8537897.</br>4: Bhagat HR, Bhargava HN, Williams DA. High-performance liquid chromatographic</br> determination of dyclonine hydrochloride in the presence of its degradation</br> products. J Pharm Biomed Anal. 1989;7(4):441-6. PubMed PMID: 2490751.</br>5: Purcell SM, Dixon SL. Allergic contact dermatitis to dyclonine hydrochloride</br> simulating extensive herpes simplex labialis. J Am Acad Dermatol. 1985 Feb;12(2</br> Pt 1):231-4. PubMed PMID: 3973123.</br>6: WHEELER DE. Bronchography using dyclonine hydrochloride anesthesia (4</br> N-butoxy-beta-piperidino-propiophenone-hydrochloride). Dis Chest. 1960</br> Feb;37:193-5. PubMed PMID: 13844280.</br>7: FLORESTANO HJ, BAHLER ME. Antimicrobial properties of dyclonine hydrochloride,</br> a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc. 1956 May;45(5):320-5. </br> PubMed PMID: 13319121.</br>8: Gargiulo AV, Burns GM, Huck CP. Dyclonine hydrochloride–a topical agent for</br> managing pain. Ill Dent J. 1992 Jul-Aug;61(4):303-4. PubMed PMID: 1286862.</br>9: Nelson LA. Nonprescription drug screening. Dyclonine hydrochloride. Am Pharm. </br> 1987 Sep;NS27(9):27-9. PubMed PMID: 3425542.</br>10: Palermo PJ. High pressure liquid chromatographic determination of dyclonine</br> hydrochloride and its degradation products in cough lozenges and liquids. J Pharm</br> Biomed Anal. 1987;5(4):423-30. PubMed PMID: 16867513.</br>11: Maibach HI. Dyclonine hydrochloride, local anaesthetic allergic contact</br> dermatitis. Contact Dermatitis. 1986 Feb;14(2):114. PubMed PMID: 3709147.</br>12: PING RS, WHITE JG, SPEAR LB. Dyclonine hydrochloride as a topical anesthetic </br> in dentistry; a preliminary report. Oral Surg Oral Med Oral Pathol. 1957</br> Jun;10(6):623-6. PubMed PMID: 13441277.</br>13: DYCLONINE hydrochloride. J Am Med Assoc. 1956 Sep 8;162(2):116-7. PubMed</br> PMID: 13357302.</br>14: MORGINSON WJ, RICH CO, ESKELSON YD, KIRKMAN LW, UTTERBACK M, BURTON AM,</br> COLETTI JM. Dyclonine hydrochloride: a new topical antipruritic agent. Postgrad</br> Med. 1956 Jun;19(6):605-7. PubMed PMID: 13335606.</br>15: FISHER HE. Dyclonine hydrochloride; evaluation of a new topical anesthetic in</br> minor urologic technics. Mo Med. 1955 Dec;52(12):943-4. PubMed PMID: 13272680.</br>16: SHELMIRE B, GASTINEAU FM, SHIELDS TL. Evaluation of a new topical anesthetic,</br> dyclonine hydrochloride. AMA Arch Derm. 1955 Jun;71(6):728-30. PubMed PMID:</br> 14375392.</br></br>

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