Donepezil - CAS 120014-06-4

Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
Target: AChE
Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively [1]. Donepezil inhibits the carbachol-stimulated increase in intracellular Ca2+ concentration in human SHSY5Y neuroblastoma cells in a concentration dependent manner, indicating that Donepezil have muscarinic antagonist activity. Intraperitoneal administration of Donepezil in rats produces a dose dependent increase in salivation and tremor, which are overt cholinergic behavioural signs, with an ED50 of 6 μmol/kg. Donepezil is found to be somewhat less potent with a ED50 of 50 μmol/kg following oral administration [2]. A recent study shows that Donepezil can protect human umbilical vein endothelial cells (HUVECs) against H2O2-induced cell injury. This may be useful as a potential therapy for oxidative stress in cardiovascular and cerebrovascular diseases [3].

Catalog Number: I000736

CAS Number: 120014-06-4

PubChem Substance ID:355039435

Molecular Formula: C24H29NO3

Molecular Weight:379.5

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: Aricept®

Property

• Molecular Formula: C24H29NO3
• Molecular Weight: 379.5
• Target: AChE
• Solubility: acetone: ~25 mg/ml
• Purity: ≥95%
• Storage: -20°C

Computed Descriptor

• InChIKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N