Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.<br>Donepezil inhibits the carbachol-stimulated increase in intracellular Ca<br>Intraperitoneal administration of Donepezil in rats produces a dose dependent increase in salivation and tremor, which are overt cholinergic behavioural signs, with an ED50 of 6 μmol/kg. Donepezil is found to be somewhat less potent with a ED50 of 50 μmol/kg following oral administration.
| Catalog Number | A000207 |
| CAS Number | 120011-70-3 |
| Synonyms | NA |
| Molecular Formula | C24H30ClNO3 |
| Purity | 95% |
| Target | Histone Acetyltransferases |
| Solubility | Limited solubility |
| Storage | 3 years -20C powder |
