Donepezil HCl - CAS 120011-70-3

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
Donepezil inhibits the carbachol-stimulated increase in intracellular Ca
Intraperitoneal administration of Donepezil in rats produces a dose dependent increase in salivation and tremor, which are overt cholinergic behavioural signs, with an ED50 of 6 μmol/kg. Donepezil is found to be somewhat less potent with a ED50 of 50 μmol/kg following oral administration.

Catalog Number: A000207

CAS Number: 120011-70-3

PubChem Substance ID:355040076

Molecular Formula: C24H30ClNO3

Molecular Weight:415.95

Purity: ≥95%

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Synonym

SynonymsNA

Property

Molecular Formula: C24H30ClNO3
Molecular Weight415.95
Target:Histone Acetyltransferases
SolubilityLimited solubility
Purity≥95%
Storage3 years -20C powder