Ranitidinebismuthcitrate

• CAT Number: M111956
• CAS Number: 128345-62-0
• Molecular Formula: C19H27BiN4O10S
• Molecular Weight: 712.483
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: bismuth;(E)-1-N/'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;2-hydroxypropane-1,2,3-tricarboxylate
• InChI: InChI=1S/C13H22N4O3S.C6H8O7.Bi/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10;/h4-5,9,14-15H,6-8,10H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;;+3/p-3/b13-9+
• InChIKey: XAUTYMZTJWXZHZ-IGUOPLJTSA-K
• SMILES: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Bi+3]

Ranitidinebismuthcitrate (CAS 128345-62-0) is a new chemical entity for the treatment of peptic ulcer disease. It was shown that Ranitidinebismuthcitrate suppressed SARS-CoV-2 replication, leading to decreased viral loads in both upper and lower respiratory tracts, and relieved virus-associated pneumonia in a golden Syrian hamster model.

Reference

1.McColm, A. A., et al. "Ranitidine bismuth citrate: a novel anti‐ulcer agent with different physico‐chemical characteristics and improved biological activity to a bismuth citrate‐ranitidine admixture." Alimentary pharmacology & therapeutics 10.3 (1996): 241-250.
2.Yuan, Shuofeng, et al. "Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters." Nature microbiology 5.11 (2020): 1439-1448.