DMOG

• CAT Number: I005353
• CAS Number: 89464-63-1
• Molecular Formula: C₆H₉NO₅
• Molecular Weight: 175.14
• Purity: ≥95%
• Target: HIF
• Solubility: water:>30 mg/ml ;DMSO: >25 mg/ml
• Storage: Store at -20°C
• IUPAC Name: methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
• InChI: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
• InChIKey: BNJOZDZCRHCODO-UHFFFAOYSA-N
• SMILES: COC(=O)CNC(=O)C(=O)OC

DMOG (Cat No.:I005353) is a compound that acts as an antagonist of the α-ketoglutarate cofactor. It inhibits HIF prolyl hydroxylase, leading to the stabilization and accumulation of HIF-1α protein in the nucleus. Consequently, DMOG acts as an agonist of HIF-1α, a transcription factor involved in cellular responses to hypoxia. Additionally, DMOG has been shown to increase autophagy, a cellular process involved in the degradation and recycling of cellular components. Its ability to modulate HIF-1α and induce autophagy makes DMOG valuable for studying cellular responses and potential therapeutic applications.

Reference

1:Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Jackson CS, Durandt C, Janse van Rensburg I, Praloran V, Brunet de la Grange P, Pepper MS.Stem Cell Res. 2017 Apr 20;21:124-131. doi: 10.1016/j.scr.2017.04.007. [Epub ahead of print] PMID: 28445828 Free Article2:Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra. Yang N, Wei Y, Wang T, Guo J, Sun Q, Hu Y, Yan X, Zhu X, Tang B, Xu Q.Sci Rep. 2016 Jul 6;6:28933. doi: 10.1038/srep28933. PMID: 27380887 Free PMC Article3:Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury. Sen T, Sen N.Neuropharmacology. 2016 Aug;107:79-88. doi: 10.1016/j.neuropharm.2016.03.009. Epub 2016 Mar 9. PMID: 26970014 4:Stabilization of Hypoxia-inducible Factor by DMOG Inhibits Development of Chronic Hypoxia-Induced Right Ventricular Remodeling. Zhang S, Ma K, Liu Y, Pan X, Chen Q, Qi L, Li S.J Cardiovasc Pharmacol. 2016 Jan;67(1):68-75. doi: 10.1097/FJC.0000000000000315. PMID: 26485211 5:Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis. Tambuwala MM, Manresa MC, Cummins EP, Aversa V, Coulter IS, Taylor CT.J Control Release. 2015 Nov 10;217:221-7. doi: 10.1016/j.jconrel.2015.09.022. Epub 2015 Sep 16. PMID: 26385165 6:A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression. Zhdanov AV, Okkelman IA, Collins FW, Melgar S, Papkovsky DB.Biochim Biophys Acta. 2015 Oct;1847(10):1254-66. doi: 10.1016/j.bbabio.2015.06.016. Epub 2015 Jul 2. PMID: 26143176 Free Article7:PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat. Yuan Q, Bleiziffer O, Boos AM, Sun J, Brandl A, Beier JP, Arkudas A, Schmitz M, Kneser U, Horch RE.BMC Biotechnol. 2014 Dec 28;14:112. doi: 10.1186/s12896-014-0112-x. PMID: 25543909 Free PMC Article8:DFO and DMOG up-regulate the expression of CXCR4 in bone marrow mesenchymal stromal cells. Wu Y, Jin A, Feng C, Zhao Y, Liu X.Pharmazie. 2013 Oct;68(10):835-8. PMID: 24273889 9:DMOG ameliorates IFN-γ-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1α degradation. Wang WS, Liang HY, Cai YJ, Yang H.J Interferon Cytokine Res. 2014 Jan;34(1):60-9. doi: 10.1089/jir.2013.0040. Epub 2013 Sep 6. PMID: 24010824