D,L-Sulforaphane

• CAT Number: R002276
• CAS Number: 4478-93-7
• Molecular Formula: C6H11NOS2
• Molecular Weight: 177.3
• Purity: ≥95%
• Synonyms: 1-Isothiocyanato-4-(methylsulfinyl)-butane; 4-Methylsulfinylbutyl Isothiocyanate; ?Sulforaphan
• Target: KEAP1-Nrf2
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• InChIKey: SUVMJBTUFCVSAD-UHFFFAOYSA-N
• SMILES: CS(CCCCN=C=S)=O

Sulforaphane(cas# 4478-93-7) is a naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale.

Reference

1: Gamet-Payrastre L. Signaling pathways and intracellular targets of
sulforaphane mediating cell cycle arrest and apoptosis. Curr Cancer Drug Targets.
2006 Mar;6(2):135-45. Review. PubMed PMID: 16529543.

2: Myzak MC, Dashwood RH. Chemoprotection by sulforaphane: keep one eye beyond
Keap1. Cancer Lett. 2006 Feb 28;233(2):208-18. Review. PubMed PMID: 16520150;
PubMed Central PMCID: PMC2276573.

3: Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer
of Phase II detoxication enzymes. Food Chem Toxicol. 1999 Sep-Oct;37(9-10):973-9.
Review. PubMed PMID: 10541453.