Daptomycin

  • CAT Number: A000562
  • CAS Number: 103060-53-3
  • Molecular Formula: C72H101N17O26
  • Molecular Weight: 1620.7
  • Purity: ≥95%
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Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. It is a naturally occurring compound found in the soil saprotroph Streptomyces roseosporus. Its distinct mechanism of action means that it may be useful in treating infections caused by multi-resistant bacteria. It is marketed in the United States under the trade name Cubicin by Cubist Pharmaceuticals.

Catalog Number A000562
CAS Number 103060-53-3
Molecular Formula

C72H101N17O26

Purity 95%
Target DNA Synthesis
Solubility >81.1mg/mL in DMSO
Storage -20°C
InChIKey DOAKLVKFURWEDJ-OFNKPWESSA-N
Reference

1: Kato H, Hagihara M, Murakami E, Suematsu H, Nishiyama N, Koizumi Y, Yamagishi
Y, Uno B, Mikamo H. Considerations about the Use of a Loading Dose of Daptomycin
in a Neutropenic Murine Thigh Infection Model with Methicillin-Resistant
Staphylococcus aureus Infection. Chemotherapy. 2017 Nov 11;63(1):13-19. doi:
10.1159/000481158. [Epub ahead of print] PubMed PMID: 29130946.
<br>

2: Kreutzberger MA, Pokorny A, Almeida PF. Daptomycin-Phosphatidylglycerol
Domains in Lipid Membranes. Langmuir. 2017 Nov 13. doi:
10.1021/acs.langmuir.7b01841. [Epub ahead of print] PubMed PMID: 29130685.

<br>
3: Belley A, Arhin FA, Moeck G. Evaluation of Oritavancin Dosing Strategies
against Vancomycin-Resistant Enterococcus faecium Isolates with or without
Reduced Susceptibility to Daptomycin in an in vitro
Pharmacokinetic/Pharmacodynamic Model. Antimicrob Agents Chemother. 2017 Nov 6.
pii: AAC.01873-17. doi: 10.1128/AAC.01873-17. [Epub ahead of print] PubMed PMID:
29109163.
<br>

4: Higashi Y, Nakamura S, Tsuji Y, Ogami C, Matsumoto K, Kawago K, Tokui K,
Hayashi R, Sakamaki I, Yamamoto Y. A Case of Daptomycin-induced Eosinophilic
Pneumonia and a Review of the Published Literature. Intern Med. 2017 Nov 1. doi:
10.2169/internalmedicine.9010-17. [Epub ahead of print] PubMed PMID: 29093391.
<br>

5: Gómez Casanova N, Siller Ruiz M, Mu&#241;oz Bellido JL. Mechanisms of resistance to
daptomycin in Staphylococcus aureus. Rev Esp Quimioter. 2017 Oct 25. pii:
gomez25oct2017. [Epub ahead of print] Review. PubMed PMID: 29082727.
<br>

6: Heidary M, Khosravi AD, Khoshnood S, Nasiri MJ, Soleimani S, Goudarzi M.
Daptomycin. J Antimicrob Chemother. 2017 Oct 20. doi: 10.1093/jac/dkx349. [Epub
ahead of print] PubMed PMID: 29059358.
<br>

7: Taylor R, Beriashvili D, Taylor S, Palmer M. Daptomycin Pore Formation Is
Restricted by Lipid Acyl Chain Composition. ACS Infect Dis. 2017 Nov
10;3(11):797-801. doi: 10.1021/acsinfecdis.7b00138. Epub 2017 Oct 23. PubMed
PMID: 29048870.

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8: Mao XM, Luo S, Li YQ. Negative regulation of daptomycin production by DepR2,
an ArsR-family transcriptional factor. J Ind Microbiol Biotechnol. 2017
Dec;44(12):1653-1658. doi: 10.1007/s10295-017-1983-3. Epub 2017 Oct 16. PubMed
PMID: 29038911.
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9: Bhardwaj P, Hans A, Ruikar K, Guan Z, Palmer KL. Reduced chlorhexidine and
daptomycin susceptibility in vancomycin-resistant Enterococcus faecium after
serial chlorhexidine exposure. Antimicrob Agents Chemother. 2017 Oct 16. pii:
AAC.01235-17. doi: 10.1128/AAC.01235-17. [Epub ahead of print] PubMed PMID:
29038276.
<br>

10: Chanderraj R, Banerjee M, Rao K. High-Dose Daptomycin and Mortality: The Case
Is Not Yet Closed. Clin Infect Dis. 2017 Oct 15;65(8):1426-1427. doi:
10.1093/cid/cix551. PubMed PMID: 29017242.

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