Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.<br>Dapoxetine not only reduces the peak amplitude of Kv4.3 currents but also accelerates the decay rate of current inactivation in a concentration-dependent manner. Dapoxetine decreases the integral of the Kv4.3 currents over the duration of a depolarizing pulse with an IC50 of 5.3 μM. Dapoxetine also causes a substantial acceleration in closed-state inactivation. Dapoxetine produces a significant use-dependent block, which is accompanied by a delayed recovery from inactivation of Kv4.3 currents.
| Catalog Number | A001071 |
| CAS Number | 129938-20-1 |
| Synonyms | LY-210448 |
| Molecular Formula | C21H23NO • HCl |
| Purity | 95% |
| Target | 5-HT Receptor |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
| InChIKey | IHWDIQRWYNMKFM-BDQAORGHSA-N |
