Dapoxetine HCl - CAS 129938-20-1

Dapoxetine HCl is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.
Dapoxetine not only reduces the peak amplitude of Kv4.3 currents but also accelerates the decay rate of current inactivation in a concentration-dependent manner. Dapoxetine decreases the integral of the Kv4.3 currents over the duration of a depolarizing pulse with an IC50 of 5.3 μM. Dapoxetine also causes a substantial acceleration in closed-state inactivation. Dapoxetine produces a significant use-dependent block, which is accompanied by a delayed recovery from inactivation of Kv4.3 currents.

Catalog Number: A001071

CAS Number: 129938-20-1

PubChem Substance ID:355038765

Molecular Formula: C21H23NO • HCl

Molecular Weight:341.9

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsLY-210448

Property

Molecular Formula: C21H23NO • HCl
Molecular Weight341.9
Target:5-HT Receptor
SolubilitySoluble in DMSO > 10 mM
Purity≥95%
Storage3 years -20C powder

Computed Descriptor

InChIKeyIHWDIQRWYNMKFM-BDQAORGHSA-N