Cyclic GMP

  • CAT Number: I025374
  • CAS Number: 7665-99-8
  • Molecular Formula: C10H12N5O7P
  • Molecular Weight: 345.2078
  • Purity: 98%
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Cyclic guanosine monophosphate (Cyclic GMP)(CAT: I025374), also known as cyclic GMP or cGMP, is a cyclic nucleotide derived from guanosine triphosphate (GTP). It serves as a critical second messenger molecule in various cellular signaling pathways. Cyclic GMP plays a key role in mediating the effects of extracellular peptide hormones that bind to cell surface receptors, leading to the activation of intracellular protein kinases. Through its interaction with specific protein kinases, cyclic GMP modulates various cellular processes, including ion channel regulation, smooth muscle relaxation, and gene expression.

Catalog Number I025374
CAS Number 7665-99-8
Synonyms

Cyclic GMP; Guanosine cyclic monophosphate; cGMP;

Molecular Formula

C10H12N5O7P

Purity 98
Solubility To be determined
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 2-amino-9-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-1,9-dihydro-6H-purin-6-one
InChI InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
InChIKey ZOOGRGPOEVQQDX-UUOKFMHZSA-N
SMILES NC1=Nc2n([C@@H]3O[C@@H]4COP(O)(O[C@H]4[C@H]3O)=O)cnc2C(N1)=O
Reference

1: Matera MG, Ora J, Cavalli F, Rogliani P, Cazzola M. New Avenues for Phosphodiesterase Inhibitors in Asthma. J Exp Pharmacol. 2021 Mar 15;13:291-302. doi: 10.2147/JEP.S242961. PMID: 33758554; PMCID: PMC7979323.

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