PhiKan 083 hydrochloride

• CAT Number: I012944
• CAS Number: 1050480-30-2
• Molecular Formula: C₁₆H₁₉ClN₂
• Molecular Weight: 274.79
• Purity: ≥95%
• Target: MDM-2/p53
• Solubility: DMSO
• Storage: Store at -20°C
• IUPAC Name: 1-(9-ethylcarbazol-3-yl)-N-methylmethanamine;hydrochloride
• InChI: InChI=1S/C16H18N2.ClH/c1-3-18-15-7-5-4-6-13(15)14-10-12(11-17-2)8-9-16(14)18;/h4-10,17H,3,11H2,1-2H3;1H
• InChIKey: IXWVUPURFWFRNE-UHFFFAOYSA-N
• SMILES: CCN1C2=C(C=C(C=C2)CNC)C3=CC=CC=C31.Cl

PhiKan 083 hydrochloride（Cat No.:I012944） is a carbazole derivative known for its ability to stabilize p53 mutant Y220C. It exhibits a Kd value of 167 μM and a relative affinity (Kd) of 150 μM in Ln229 cells. PhiKan 083 is utilized in cancer research due to its potential in targeting and modulating the p53 pathway, which plays a crucial role in tumor suppression. By stabilizing the Y220C mutant, PhiKan 083 may offer insights into developing therapeutic strategies for cancers associated with this specific p53 mutation.

Reference

[1]. Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.