Stattic - CAS 19983-44-9
Stattic is a potent inhibitor of STAT3, used for cancer treatment.
IC50 value:
Target:
In vitro: Stattic inhibits STAT3 phosphorylation (Y705) in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines at a higher concenration (20 μM). Stattic selectively inhibited P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in both ALDH+ and CD44+/CD24+ subpopulations of Panc-1 and HPAC. Stattic inhibita STAT3 downstream targets in ALDH+ and CD44+/CD24+ subpopulations of pancreatic cancer cells[1]. Stattic reduces the LPS-induced expression of ICAM-1 and VCAM-1, and STAT3 phosphorylation[3].
In vivo:
Catalog Number: I002533
CAS Number: 19983-44-9
PubChem Substance ID:355036872
Molecular Formula: C₈H₅NO₄S
Molecular Weight:211.19
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
| Synonyms | 6-nitro-1-benzothiophene 1,1-dioxide |
|---|
Property
| Molecular Formula: | C₈H₅NO₄S |
|---|---|
| Molecular Weight | 211.19 |
| Target: | STAT |
| Solubility | 10 mM in DMSO |
| Purity | ≥95% |
| Storage | 3 years -20C powder |
| MDL | MFCD00173799 |
Computed Descriptor
| InChI | InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H |
|---|---|
| InChIKey | ZRRGOUHITGRLBA-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] |