Cobimetinib hemifumarate

• CAT Number: I020490
• CAS Number: 1369665-02-0
• Molecular Formula: C₂₁H₂₁F₃IN₃O₂.₁/₂C₄H₄O₄
• Molecular Weight: 589.25
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: (E)-but-2-enedioic acid;[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone
• InChI: InChI=1S/2C21H21F3IN3O2.C4H4O4/c2*22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17;5-3(6)1-2-4(7)8/h2*4-7,9,17,26-27,30H,1-3,8,10-11H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*17-;/m00./s1
• InChIKey: RESIMIUSNACMNW-BXRWSSRYSA-N
• SMILES: C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O.C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O.C(=CC(=O)O)C(=O)O

Cobimetinib hemifumarate (Cat No.:I020490) is a potent and selective inhibitor of MEK1 and MEK2, key enzymes in the MAPK signaling pathway. It is used in the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations. By blocking the activity of MEK1/2, Cobimetinib hemifumarate helps to inhibit tumor cell growth and proliferation. It is often administered in combination with a BRAF inhibitor for enhanced therapeutic efficacy. Cobimetinib hemifumarate has demonstrated promising results in clinical trials and provides a targeted approach for managing advanced melanoma.

Reference

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