For research use only. Not for therapeutic Use.
Clomethiazole (CAT: R018287) is a thiazole-derived sedative and hypnotic agent with potent GABAergic activity. It acts primarily as a positive allosteric modulator of GABAAreceptors, producing strong sedative, anticonvulsant, and neuroprotective effects. Clomethiazole has been used clinically for the treatment of acute alcohol withdrawal syndrome, insomnia, and agitation in elderly patients. In research, it is studied for its ability to reduce neuronal excitability, protect against ischemic brain injury, and modulate central nervous system disorders. Its pharmacological profile makes it valuable in neuroscience and neurodegeneration research involving GABAergic signaling.
| CAS Number | 533-45-9 |
| Synonyms | 5-(2-chloroethyl)-4-methyl-1,3-thiazole |
| Molecular Formula | C6H8ClNS |
| Purity | ≥95% |
| IUPAC Name | 5-(2-chloroethyl)-4-methyl-1,3-thiazole |
| InChI | InChI=1S/C6H8ClNS/c1-5-6(2-3-7)9-4-8-5/h4H,2-3H2,1H3 |
| InChIKey | PCLITLDOTJTVDJ-UHFFFAOYSA-N |
| SMILES | CC1=C(SC=N1)CCCl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
