Macimorelin (CAT: I007900), also known as AEZS-130, EP-1572, or JMV1843, is a novel synthetic small molecule, acting as a ghrelin agonist, that is orally active and stimulates the secretion of growth hormone (GH). Based on the results of Phase 1 studies, AEZS-130 has potential applications for treating cachexia, a condition frequently associated with severe chronic diseases such as cancer, chronic obstructive pulmonary disease, and AIDS. In addition to the therapeutic application, a Phase 3 trial with AEZS-130 as a diagnostic test for adult growth hormone deficiencies has been completed.
| Catalog Number | I007900 |
| CAS Number | 381231-18-1 |
| Synonyms | JMV1843; JMV-1843; JMV 1843; AEZS-130; AEZS 130; AEZS130; EP-1572; EP 1572; EP1572; UMV-1843; UMV 1843; Macimorelin; AibDTrpDgTrpCHO.;2-amino-N-((R)-1-(((R)-1-formamido-2-(1H-indol-3-yl)ethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-methylpropana |
| Molecular Formula | C26H30N6O3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| Overview of Clinical Research | <p> |
| IUPAC Name | 2-amino-N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide |
| InChI | InChI=1S/C26H30N6O3/c1-26(2,27)25(35)31-22(11-16-13-28-20-9-5-3-7-18(16)20)24(34)32-23(30-15-33)12-17-14-29-21-10-6-4-8-19(17)21/h3-10,13-15,22-23,28-29H,11-12,27H2,1-2H3,(H,30,33)(H,31,35)(H,32,34)/t22-,23-/m1/s1 |
| InChIKey | UJVDJAPJQWZRFR-DHIUTWEWSA-N |
| SMILES | CC(C)(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CNC4=CC=CC=C43)NC=O)N |
| Reference | <br /> |
