Chloroxine

• CAT Number: A000829
• CAS Number: 773-76-2
• Molecular Formula: C9H5Cl2NO
• Molecular Weight: 214.05
• Purity: ≥95%
• Storage: -20°C
• InChI: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
• InChIKey: WDFKMLRRRCGAKS-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1

Chloroxine is a synthetic antibacterial agent. It inhibits the growth of Gram-positive and some Gram-negative bacteria and also induces SOS-DNA repair. Chlorxine shows bacteriostatic, fungistatic and antiprotozoal effects in vivo.

Reference

1: Pérez-Ruiz T, Martínez-Lozano C, Tomás V, Carpena J. Fluorimetric
determination of chloroxine using manual and flow-injection methods. J Pharm
Biomed Anal. 1996 Aug;14(11):1505-11. PubMed PMID: 8877856.

2: Negosanti M, Bettoli V, Valenti R, Patrone P, Celasco G. [Clinical evaluation
on the usefulness of 5,7-dichloro-8-hydroxyquinoline (chloroxine) in association
with betamethasone 17-benzoate in the topical treatment of infected
cortisone-sensitive dermopathies]. G Ital Dermatol Venereol. 1985
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3: Johnson ML. Fluorescence with chloroxine shampoo. Arch Dermatol. 1979
May;115(5):641. PubMed PMID: 443855.

4: Stocchi F. [Clinical tests of topical preparations containing betamethasone
17-benzoate and the same associated with 5,7-dichloro-8-hydroxyquinoline
(chloroxine)]. Clin Ter. 1977 Nov 30;83(4):359-69. Italian. PubMed PMID: 603986.

5: Chládek S, Zemlicka J, Gut V. 5-chloro-8-hydroxyquinoline (chloroxine) esters
of carboxylic acid–selective reagents for acylation of nucleoside and nucleotide
aminoacyl derivatives. Biochem Biophys Res Commun. 1969 Apr 29;35(2):306-11.
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