Ceftibuten dihydrate

• CAT Number: I000642
• CAS Number: 118081-34-8
• Molecular Formula: C15H18N4O8S2
• Molecular Weight: 446.46
• Purity: ≥95%
• Target: C1C=C(N2C(S1)C(C2=O)NC(=O)C(=CCC(=O)O)C3=CSC(=N3)N)C(=O)O.O.O
• Solubility: DMSO:35mg/mL
• Storage: 3 years -20C powder
• InChI: InChI=1S/C15H14N4O6S2.2H2O/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19;;/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25);2*1H2/b6-1-;;/t10-,13-;;/m1../s1
• InChIKey: SSWTVBYDDFPFAF-DKOGRLLHSA-N

Ceftibuten (Cat.No:I000642) is an orally active third-generation cephalosporin that exhibits good microbiologic activity against many gram-negative and select gram-positive organisms. It is stable against plasmid-mediated beta-lactamases, including extended-spectrum beta-lactamases. 

Reference

1: Hayashi I, Onuma K, Hasuike M, Ishii T. [Clinical examination of ceftibuten in
acute bronchitis]. Jpn J Antibiot. 1990 May;43(5):761-7. Japanese. PubMed PMID:
2391747.

2: Hashimoto H, Yamaguchi S, Yachiku S. [Clinical studies of ceftibuten in the
field of urology]. Jpn J Antibiot. 1990 Feb;43(2):355-61. Japanese. PubMed PMID:
2362357.

3: Jones RN, Barry AL. Ceftibuten (7432-S, SCH 39720): comparative antimicrobial
activity against 4735 clinical isolates, beta-lactamase stability and broth
microdilution quality control guidelines. Eur J Clin Microbiol Infect Dis. 1988
Dec;7(6):802-7. PubMed PMID: 3145869.

4: Jones RN, Barry AL. In vitro evaluation of ceftibuten (7432-S, SCH 39720), a
novel orally administered cephalosporin. Chemioterapia. 1988 Oct;7(5):283-6.
PubMed PMID: 3147148.