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CCT007093

CCT007093

  • CAT Number: I002302
  • CAS Number: 176957-55-4
  • Molecular Formula: C15H12OS2
  • Molecular Weight: 272.4
  • Purity: ≥95%
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CCT007093 (Cat.No:I002302) is an inhibitor of protein phosphatase 1D (PPM1D/Wip1). Inhibition of Wip1 can activate the mTORC1 pathway, enhancing liver cell proliferation after hepatectomy. In vitro studies show that CCT007093 has specific effects on MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells. In vivo, CCT007093 enhances liver regeneration and increases the survival rate of mice following major hepatectomy.

Catalog Number I002302
CAS Number 176957-55-4
Synonyms

(2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one

Molecular Formula

C15H12OS2

Purity 95%
Target Protein Ser/Thr Phosphatases
Solubility DMSO: ≥ 2.7 mg/mL, DMSO: ＜ 5.1 mg/mL
Storage Store at -20℃
IUPAC Name (2E,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one
InChI InChI=1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+
InChIKey KPFZCKDPBMGECB-WGDLNXRISA-N
SMILES O=C(/C(CC/1)=C/C2=CC=CS2)C1=CC3=CC=CS3
Reference

<p style=/line-height:25px/>
<br>[1]. Rayter S, et al. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.
<br>[2]. Buss MC, et al. HDM2 promotes WIP1-mediated medulloblastoma growth. Neuro Oncol. 2012 Apr;14(4):440-58.
<br>[3]. Lee JS, et al. Off-target response of a Wip1 chemical inhibitor in skin keratinocytes. J Dermatol Sci. 2014 Feb;73(2):125-34.
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