Capreomycin sulfate

• CAT Number: I001559
• CAS Number: 1405-37-4
• PubChem Substance ID: 22836615
• Molecular Formula: C24H42N14O8 • H2SO4
• Molecular Weight: 752.8
• Purity: 99%
• Solubility: H2O: ≥ 37 mg/mL
• Storage: -20°C
• Analysis method: HPLC
• IUPAC Name: (2S)-2,5-diamino-N-[[(2S,5S,8Z,11S,15S)-15-amino-11-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]pentanamide;sulfuric acid
• InChI: InChI=1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41)(H,38,43)(H3,28,30,37)(H3,29,33,46);(H2,1,2,3,4)/b14-8-;/t10-,11-,12?,13-,15-,16-;/m0./s1
• InChIKey: LFFNIXQXRKNZCE-XYHGUWSSSA-N
• SMILES: C1CN=C(NC1C2C(=O)NCC(C(=O)NC(C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)N2)CNC(=O)C(CCCN)N)CO)N)N.OS(=O)(=O)O

Capreomycin sulfate (CAT: I001559) is an antibiotic drug that belongs to the class of cyclic peptide antibiotics known as capreomycins. It is primarily used in the treatment of multi-drug resistant tuberculosis (MDR-TB) infections. Capreomycin sulfate exerts its antimicrobial activity by inhibiting protein synthesis in bacteria. It specifically targets the 70S ribosome complex and disrupts the translocation process, leading to the inhibition of bacterial protein synthesis. Due to its potent activity against drug-resistant strains of Mycobacterium tuberculosis, capreomycin sulfate is an important component of combination therapy for the management of MDR-TB.

Reference

[1]. Johansen SK, et al. Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2/'-O-methylations in 16S and 23S rRNAs. Mol Cell. 2006 Jul 21;23(2):173-82.