Calpeptin

• CAT Number: R029868
• CAS Number: 117591-20-5
• Molecular Formula: C20H30N2O4
• Molecular Weight: 362.5
• Purity: ≥95%
• Target: Calpains
• Solubility: Soluble in DMSO > 10 mM
• Storage: Desiccate at 4°C
• InChIKey: PGGUOGKHUUUWAF-ROUUACIJSA-N

Calpeptin is a rho kinase activator and an inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in apoptosis, long-term potentiation in neurons, and cell cycle progression. Calpeptin attenuates apoptosis and inflammation, cell death, and axonal damage in animal model of multiple sclerosis. Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx.

Reference

1:Calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model. Yoshida M, Miyasaka Y, Ohuchida K, Okumura T, Zheng B, Torata N, Fujita H, Nabae T, Manabe T, Shimamoto M, Ohtsuka T, Mizumoto K, Nakamura M.Cancer Sci. 2016 Oct;107(10):1443-1452. doi: 10.1111/cas.13024. Epub 2016 Sep 24. PMID: 27487486 Free PMC Article2:Calpeptin Prevents Malignant Pleural Mesothelioma Cell Proliferation via the Angiopoietin1/Tie2 System. Tabata C, Tabata R, Nakano T.Asian Pac J Cancer Prev. 2016;17(7):3405-9. PMID: 27509983 Free Article3:Neuroprotective Effect of Calpeptin on Acrylamide-Induced Neuropathy in Rats. Wei X, Yan F, E M, Zhang C, Li G, Yang X, Zhang F, Wang S, Yu S.Neurochem Res. 2015 Nov;40(11):2325-32. doi: 10.1007/s11064-015-1722-y. Epub 2015 Sep 30. PMID: 26423962 4:Calpeptin, not calpain, directly inhibits an ion channel of the inner mitochondrial membrane. Derksen M, Vorwerk C, Siemen D.Protoplasma. 2016 May;253(3):835-43. doi: 10.1007/s00709-015-0846-x. Epub 2015 Jun 25. PMID: 26108743 5:[The effect of calpeptin on injury and atrophy of diaphragm under mechanical ventilation in rats]. Shi L, Guo H, Huang J, Ma S, Chen X, Zhu X.Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Aug;26(8):549-53. doi: 10.3760/cma.j.issn.2095-4352.2014.08.005. Chinese. PMID: 25124902 Free Article6:Proteomic study of calpeptin-induced differentiation on calpain-interacting proteins of C2C12 myoblast. Singh NK, Shiwani S, Hwang IH.In Vitro Cell Dev Biol Anim. 2012 Mar;48(3):175-85. doi: 10.1007/s11626-012-9484-1. Epub 2012 Jan 21. PMID: 22271316 7:Calpeptin attenuated apoptosis and intracellular inflammatory changes in muscle cells. Nozaki K, Das A, Ray SK, Banik NL.J Neurosci Res. 2011 Apr;89(4):536-43. doi: 10.1002/jnr.22585. Epub 2011 Feb 2. PMID: 21290412 Free PMC Article8:The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. Tabata C, Tabata R, Nakano T.Clin Exp Immunol. 2010 Dec;162(3):560-7. doi: 10.1111/j.1365-2249.2010.04257.x. Epub 2010 Sep 15. PMID: 20846163 Free PMC Article9:Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis. Guyton MK, Das A, Samantaray S, Wallace GC 4th, Butler JT, Ray SK, Banik NL.J Neurosci Res. 2010 Aug 15;88(11):2398-408. doi: 10.1002/jnr.22408. PMID: 20623621 Free PMC Article10:The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats. Peng S, Kuang Z, Zhang Y, Xu H, Cheng Q.Mol Biol Rep. 2011 Feb;38(2):905-12. doi: 10.1007/s11033-010-0183-2. Epub 2010 May 16. PMID: 20473717