Brivanib Alaninate

• CAT Number: I004451
• CAS Number: 649735-63-7
• Molecular Formula: C₂₂H₂₄FN₅O₄
• Molecular Weight: 441.46
• Purity: ≥95%
• Synonyms: [(2R)-1-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-yl] (2S)-2-aminopropanoate
• Target: VEGFR
• Solubility: ≥22.05 mg/mL in DMSO; insoluble in H2O; ≥10.03 mg/mL in EtOH
• Storage: Store at -20°C
• IC50: 25 nM
• InChI: InChI=1S/C22H24FN5O4/c1-11-7-15-16(27-11)5-6-17(19(15)23)32-21-20-13(3)18(8-28(20)26-10-25-21)30-9-12(2)31-22(29)14(4)24/h5-8,10,12,14,27H,9,24H2,1-4H3/t12-,14+/m1/s1
• InChIKey: LTEJRLHKIYCEOX-OCCSQVGLSA-N
• SMILES: CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)OC(=O)C(C)N)C

Brivanib Alaninate (Cat No.:I004451) is a prodrug of BMS-540215. It acts as an ATP-competitive inhibitor of VEGFR2 (vascular endothelial growth factor receptor 2) with an IC50 value of 25 nM. By targeting VEGFR2, Brivanib Alaninate inhibits angiogenesis, the process of blood vessel formation, which is important in tumor growth and progression. It has been investigated for its potential use in cancer therapy, particularly in the treatment of solid tumors.

Reference

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