For research use only. Not for therapeutic Use.
Brevetoxin PbTx-3（Cat No.:T000082）is a water-soluble marine neurotoxin produced by the dinoflagellate Karenia brevis, a key organism in red tide events. As a member of the polyether brevetoxin family, PbTx-3 binds to site 5 of voltage-gated sodium channels, leading to persistent channel activation, altered ion flux, and neurotoxicity. It is less lipophilic than PbTx-2 but retains significant potency and bioactivity. PbTx-3 is a primary cause of neurotoxic shellfish poisoning (NSP) and is studied for its ecological, toxicological, and pharmacological implications, especially regarding marine ecosystem disruption and human health risks.
| CAS Number | 85079-48-7 |
| Molecular Formula | C50H72O14 |
| Purity | ≥95% |
| Target | Sodium Channel |
| Solubility | In acetone, ethyl acetate, methanol, ethanol, water. |
| Storage | Brevetoxins are unusually stable materials in the dry state under vacuum. It is recommended that PbTx-3 be stored at -20°C in its original unopened vial until use. Once opened, PbTx-3 should be dissolved in an appropriate solvent like acetone, acet |
| IUPAC Name | (21Z)-12-hydroxy-14-[2-(hydroxymethyl)prop-2-enyl]-1,3,11,24,31,41,44-heptamethyl-2,6,10,15,19,25,29,34,38,43,47-undecaoxaundecacyclo[26.22.0.03,26.05,24.07,20.09,18.011,16.030,48.033,46.035,44.037,42]pentaconta-21,40-dien-39-one |
| InChI | InChI=1S/C50H72O14/c1-25(24-51)14-28-17-37(52)50(8)41(54-28)19-33-34(61-50)18-32-29(55-33)10-9-12-46(4)42(58-32)23-49(7)40(62-46)21-39-47(5,64-49)13-11-30-44(60-39)26(2)15-31-36(56-30)22-48(6)38(57-31)20-35-45(63-48)27(3)16-43(53)59-35/h9-10,16,26,28-42,44-45,51-52H,1,11-15,17-24H2,2-8H3/b10-9- |
| InChIKey | BKMHDYJRAAJTAD-KTKRTIGZSA-N |
| SMILES | CC1CC2C(CC3(C(O2)CC4C(O3)C(=CC(=O)O4)C)C)OC5C1OC6CC7C(CC8C(O7)(C/C=C\C9C(O8)CC1C(O9)CC2C(O1)(C(CC(O2)CC(=C)CO)O)C)C)(OC6(CC5)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
